Glanzmann's thrombasthenia physical examination
Glanzmann's thrombasthenia |
Differentiating Glanzmann's thrombasthenia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Niyousha Danesh, MD-MPH
Overview
Patients with Glanzmann’s thrombasthenia may be asymptomatic, or they could manifest mucosal bleeding, ecchymoses,petechiae and purpura or current bleeding on physical exam.[1]
Physical examination
Appearance of the Patient
- Patient appears well in the absence of severe hemorrhage
- Patient appears ill in the persistent bleeding .
Vital Signs
- may haveTachycardia, depends on the severity of the bleeding.
- may haveTachypnea depends on severity of the bleeding
Skin
- Cyanosis
- Pallor
- Secondary to anemia
- Ecchymoses,petechiae and purpura
- Secondary to thrombocytopenia
HEENT
- Evidence of trauma
- pale conjunctiva
- Epistaxis
- palatal petechiae
- gingival or other oral cavity bleeding.
Neck
No specific sign.
Lungs
- commonly normal lung sounds.
Heart
- commonly normal heart sounds
Abdomen
The spleen is usually non palpable.
Neuromuscular
- Patient is usually oriented to persons, place, and time
- Glasgow coma scale is normally 15 / 15 but may may present loss of consciousness in severe fatal hemorrhage episodes. [2]
Gallery
Extremities
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Glanzmann’s trombastenia. With permission from Dermatology Atlas.[3]
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Glanzmann’s trombastenia. With permission from Dermatology Atlas.[3]
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Glanzmann’s trombastenia. With permission from Dermatology Atlas.[3]
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Glanzmann’s trombastenia. With permission from Dermatology Atlas.[3]
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Glanzmann’s trombastenia. With permission from Dermatology Atlas.[3]
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Glanzmann’s trombastenia. With permission from Dermatology Atlas.[3]
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Glanzmann’s trombastenia. With permission from Dermatology Atlas.[3]
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Glanzmann’s trombastenia. With permission from Dermatology Atlas.[3]
References
- ↑ Nurden AT, Pillois X, Wilcox DA (2013). "Glanzmann thrombasthenia: state of the art and future directions". Semin Thromb Hemost. 39 (6): 642–55. doi:10.1055/s-0033-1353393. PMC 4011384. PMID 23929305.
- ↑ Nurden AT (2006). "Glanzmann thrombasthenia". Orphanet J Rare Dis. 1: 10. doi:10.1186/1750-1172-1-10. PMC 1475837. PMID 16722529.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 "Dermatology Atlas".