Sandbox: wdx causes
Differentiating Leukocytosis from Other Diseases
- There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing (complete blood count).
| Category | Condition | Etiology | Mechanism | Congenital | Acquried | Clinical manifestations | Para−clinical findings | Gold standard | Associated findings | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Demography | History | Symptoms | Signs | |||||||||||||||||||||||
| Lab Findings | ||||||||||||||||||||||||||
| Appearance | Fever | Bleeding | BP | Splenomegaly | Jaundice | Other | CBC | PBS | Bone marrow exam | PT | PTT | UA | ||||||||||||||
| Physiologic | Primary | Secondary | Plt | HB | WBC | |||||||||||||||||||||
| Hematologic | Hereditary neutrophilia | |||||||||||||||||||||||||
| Chronic idiopathic neutrophilia | ||||||||||||||||||||||||||
| CML | ||||||||||||||||||||||||||
| Polycythemia Vera | ||||||||||||||||||||||||||
| Hemolytic anemia | Marrow stimulation | |||||||||||||||||||||||||
| Immature thrombocytopenia | Marrow stimulation | |||||||||||||||||||||||||
| Immunology/
Rheumatology |
Condition | Etiology | Bone marrow infiltration | Bone marrow failure | Destruction/
sequestration/ redistribution |
Congenital | Acquried | Demography | History | Appearance | Fever | Bleeding | BP | Splenomegaly | Jaundice | Other signs | Plt | HB | WBC | PBS | Bone marrow exam | PT | PTT | UA | Gold standard | Associated findings |
| RA | ||||||||||||||||||||||||||
| JRA | ||||||||||||||||||||||||||
| IBD | ||||||||||||||||||||||||||
| Chronic hepatitis | ||||||||||||||||||||||||||
| Acute Gout | ||||||||||||||||||||||||||
| Metabolic | Diabetic coma | |||||||||||||||||||||||||
| Acidosis | ||||||||||||||||||||||||||
| Thyroid strom | ||||||||||||||||||||||||||
| Seizures | ||||||||||||||||||||||||||
| Infections | Condition | Etiology | Bone marrow infiltration | Bone marrow failure | Destruction/
sequestration/ redistribution |
Congenital | Acquried | Demography | History | Appearance | Fever | Bleeding | BP | Splenomegaly | Jaundice | Other signs | Plt | HB | WBC | PBS | Bone marrow exam | PT | PTT | UA | Gold standard | Associated findings |
| Acute | ||||||||||||||||||||||||||
| Chronic | ||||||||||||||||||||||||||
| Medications | Steriod | |||||||||||||||||||||||||
| Lithium | ||||||||||||||||||||||||||
| Beta agonists | ||||||||||||||||||||||||||
| Cytokines | ||||||||||||||||||||||||||
| Other | Post splenectomy | |||||||||||||||||||||||||
| Down syndrome | ||||||||||||||||||||||||||
| Birth | ||||||||||||||||||||||||||
| Pregnancy | ||||||||||||||||||||||||||
| Category | Condition | Etiology | Bone marrow infiltration | Bone marrow failure | Destruction/
sequestration/ redistribution |
Congenital | Acquried | Demography | History | Appearance | Fever | Bleeding | BP | Splenomegaly | Jaundice | Other signs | Plt | HB | WBC | PBS | Bone marrow exam | PT | PTT | UA | Gold standard | Associated findings |
- Leukocytosis is defined as an elevated white blood cell (WBC) count greater than 11,000 per mm3 (11.0 × 109 per L).
- The most common type of leukocytosis is neutrophilia.
- Neutrophilia can be defined as an increase in the absolute number of mature neutrophils to greater than 7,000 per mm3 [7.0 × 109 per L].