Waldenström's macroglobulinemia bone marrow aspiration and biopsy

Waldenström's macroglobulinemia Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Bone Marrow Aspirate

Findings in Bone Marrow Aspirate Bone marrow aspirate is frequently hypocellular. Findings in Bone Marrow Biopsy Biopsy specimen is usually hypercellular and infiltrated with lymphoid and plasmacytoid cells. Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) are the characteristic features of waldenström's macroglobulinemia. Three patterns of marrow involvement are described, as follows: Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern Lymphoplasmacytic cells (small lymphocytes, mature plasma cells, mast cells) in an interstitial/nodular pattern A polymorphous infiltrate (small lymphocytes, plasma cells, plasmacytoid cells, immunoblasts with mitotic figures)