Waldenström's macroglobulinemia electrophoresis and immunofixation
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]
Overview
Serum protein electrophoresis and immunofixation are important for the diagnosis of Waldenström's macroglobulinemia.
Electrophoresis and Immunofixation
Serum protein electrophoresis is important for the diagnosis of Waldenström's macroglobulinemia. Findings on an electrophoresis diagnostic of Waldenström's macroglobulinemia include:[1]
- Sharp narrow spike of monoclonal IgM protein
- Dense band of monoclonal IgM protein
Serum immunofixation is important for the diagnosis of Waldenström's macroglobulinemia. It helps in confirming the presence of a monoclonal protein in addition to determining its type.[1]
References
- ↑ 1.0 1.1 Riches PG, Sheldon J, Smith AM, Hobbs JR (1991). "Overestimation of monoclonal immunoglobulin by immunochemical methods". Ann Clin Biochem. 28 ( Pt 3): 253–9. doi:10.1177/000456329102800310. PMID 1872571.