Hairy cell leukemia diagnotic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

Bone marrow (BM) aspirate, peripheral blood and trephine biopsies are the gold standard test for the diagnosis of hairy cell leukemia.

Diagnostic Study of Choice

Study of choice

Peripheral blood smear:

Peripheral blood smears is one of the gold standard test for the diagnosis of hairy cell leukemia.

The following result of peripheral blood smears is confirmatory of hairy cell leukemia:[1]

  • Oval nuclei and abundant cytoplasm with "hairy" projections
  • Fried egg appearance
  • Loose chromatin
  • Mast cells numbers elevation
  • Extravasated red cells are positive in peripheral blood smear of hairy cell leukemia patients

Bone marrow

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  1. ↑ Cazzola, M. (2016). "Introduction to a review series: the 2016 revision of the WHO classification of tumors of hematopoietic and lymphoid tissues". Blood. 127 (20): 2361–2364. doi:10.1182/blood-2016-03-657379. ISSN 0006-4971.
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