Glanzmann's thrombasthenia diagnostic study of choice

Glanzmann's thrombasthenia
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2], Niyousha Danesh, MD-MPH

Overview

Platelet aggregation assays — Traditional platelet aggregation assays employ a panel of platelet agonists to measure platelet activation and aggregation in vitro. Either whole blood or platelet-rich plasma is used depending on the technique. Since many common medications can affect platelet function, care must be taken to avoid their use in patients prior to testing. Common agonists used in these assays include ADP, arachidonic acid, collagen, epinephrine, thrombin, and ristocetin. Platelet function testing", section on 'Platelet aggregometry'.)

Diagnostic study of choice

There is no single diagnostic study of choice for the diagnosis of Glanzmann's thrombasthenia, but it can be diagnosed based on Platelet aggregation assays — Traditional platelet aggregation assays employ a panel of platelet agonists to measure platelet activation and aggregation in vitro. Either whole blood or platelet-rich plasma is used depending on the technique. Since many common medications can affect platelet function, care must be taken to avoid their use in patients prior to testing. Common agonists used in these assays include ADP, arachidonic acid, collagen, epinephrine, thrombin, and ristocetin. (See "Platelet function testing", section on 'Platelet aggregometry'.)