Lymphomatoid granulomatosis pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Lymphomatoid granulomatosis arises from T cells, which are Lymphoid cells that are normally involved in Immunity.
Pathophysiology
Physiology
The normal physiology of cell mediated immunity can be understood as follows: Historically, the immune system was divided into two branches: humoral immunity, for which the defending function of immunization could be seen in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the defending function of immunization was associated with cells. CD4 cells or helper T cells provide defense against varying pathogenic organisms. Naive T cells, mature T cells that have yet to come upon an antigen, are transformed into activated effector T cells after coming across an antigen-presenting cells (APCs). These APCs, such as macrophages, dendritic cells, and B cells in some cases, pack antigenic peptides onto the MHC of the cell, in turn introducing the peptide to receptors on T cells. The most important of these APCs are highly specialized dendritic cells; conceivably operating solely to ingest and present antigens.[1]
Pathogenesis
- It is understood that Lymphomatoid granulomatosis is seen in extranodal sites, most commonly the lung. Other recurrent sites of involvement include kidney, skin, central nervous system and liver. The pattern of necrosis in both Lymphomatoid granulomatosis and T/Natural killer cell lymphoma is very similar, accentuating the probable importance of EBV in interceding the vascular damage. Recent studies shows that the chemokines IP-10 and Monoclonal immunoglobilins in the pathogenesis of the vascular damage. Although the most common infiltrating cells are T cells, the T cell receptor genes are not clonally rearranged. However, by VDJ polymerase chain reaction, approximately 60% of cases contain clonal rearrangements. EBV sequences can be confined to B cells and are clonal in most cases. Most patients with Lymphomatoid granulomatosis carefully evaluated clinically have irregularities in there cytotoxic T cell function and low levels of CD8+ T cells[2][3]Associated Conditions==
Conditions associated with [disease name] include:
- [Condition 1]
- [Condition 2]
- [Condition 3]
Gross Pathology
On gross pathology,
Microscopic Pathology
On microscopic histopathological analysis, the presence of an angiocentric and angiodestructive accumulation of differing numbers of T cells with varying numbers of atypical clonal EBV-positive B cells in a polymorphous inflammatory background is seen in Lymphomatoid granulomatosis
References
- ↑ Denburg JA, Bienenstock J (March 1979). "Physiology of the immune response". Can Fam Physician. 25: 301–7. PMC 2382958. PMID 21297689.
- ↑ Jaffe ES, Wilson WH (1997). "Lymphomatoid granulomatosis: pathogenesis, pathology and clinical implications". Cancer Surv. 30: 233–48. PMID 9547995.
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMC 5922622. PMID https://doi.org/10.1016/S0046-8177(72)80005-4 Check
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