Hodgkin's lymphoma historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Hodgkin's lymphoma was first discovered by Thomas Hodgkin, a British physician, in 1832.
Historical Perspective
- Hodgkin's lymphoma was first described by Thomas Hodgkin, a British physician, in 1832.Although earliest description for this disease was provided by Marcello Malpighi in 1666.[1][2]
- Hodgkin's report entitled "On some morbid appearances of the absorbent glands and spleen", was presented to the Medical and Chirurgical Society in London in 1832.[1] Hodgkin's paper went largely unnoticed, however, even despite Bright highlighting it in an 1838 publication.[1] Indeed, Hodgkin himself did not view his contribution as particularly significant.[3]
- In 1856, Samuel Wilks independently reported on a series of patients with the same disease that Hodgkin had previously described.[3] Wilks, a successor to Hodgkin at Guy's Hospital, was unaware of Hodgkin's prior work on the subject. Bright made Wilks aware of Hodgkin's contribution and in 1865, Wilks published a second paper, entitled "Cases of enlargement of the lymphatic glands and spleen", in which he called the disease "Hodgkin's disease" in honor of his predecessor.[3]
- Theodor Langhans and WS Greenfield first described the microscopic characteristics of Hodgkin's lymphoma in 1872 and 1878, respectively.[1]
- In 1898 and 1902, respectively, Carl Sternberg, and Dorothy Reed independently described the cytogenetic features of the malignant cells of Hodgkin's lymphoma, now called Reed–Sternberg cells.[1]
- Tissue specimens from Hodgkin's seven patients remained at Guy's Hospital for a number of years. Nearly 100 years after Hodgkin's initial publication, histopathologic reexamination confirmed Hodgkin's lymphoma in only three of seven of these patients.[3] The remaining cases included non-Hodgkin lymphoma, tuberculosis, and syphilis.[3]
- Hodgkin's lymphoma was one of the first cancers which could be treated using radiation therapy and, later, it was one of the first to be treated by combination chemotherapy.
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Photograph from a 1938 medical textbook labeled "Hodgkin's Disease".
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Hellman S (2007). "Brief Consideration of Thomas Hodgkin and His Times". In Hoppe RT, Mauch PT, Armitage JO, Diehl V, Weiss LM. Hodgkin Lymphoma (2nd ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. pp. 3–6. ISBN 0-7817-6422-X.
- ↑ Hodgkin T (1832). "On some morbid experiences of the absorbent glands and spleen". Med Chir Trans. 17: 69–97.
- ↑ 3.0 3.1 3.2 3.3 3.4 Geller SA (August 1984). "Comments on the anniversary of the description of Hodgkin's disease". Journal of the National Medical Association. 76 (8): 815–7. PMC 2609834. PMID 6381744.