Sandbox:Shadan
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]
Overview
Classification
Classification of breast lumps based on epithelial hyperplasia[1]
- Approximately 65% of all BBD considered as nonproliferative(NP)with relative cancer risk of 1.2, 1.4 times:
- Simple cyst
- Fibrosis
- Fibroadenoma (simple)
- Columnar alteration (Simple)
- Apocrine metaplasia (simple)
- Mild ductal hyperplasia
- Apocrine metaplasia (simple)
- Columnar alteration (Simple)
- Fibroadenoma (simple)
- Approximately 30% of total are classifed as [[proliferative disease(PD) with relative cancer risk of 1.7, 2.1 times
- Usual ductal hyperplasia
- Sclerosing adenosis
- Columnar hyperplasia
- Sclerosing adenosis
***** papilloma
****** Radical scar
*** Approximately 5% to 8% of the rest regarded to PD with atypiawith relative cancer risk more than 4 times
*** Atypical lobar hyperplasia
**** Lobular carcinoma in situ
***** Atypical ductal hyperplasia
**** Unclear risk
**** Mucocele like tumor
***** Apocrine atypia
****** Secretory atypia
References
- ↑ Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K; et al. (2005). "Benign breast disease and the risk of breast cancer". N Engl J Med. 353 (3): 229–37. doi:10.1056/NEJMoa044383. PMID 16034008.