Sandbox:Shadan
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]
Overview
Classification
Classification of breast lumps based on epithelial hyperplasia[1]
- Approximately 65% of all benign breast disease considered as nonproliferative(NP)with relative cancer risk of 1.2, 1.4 times:
- Simple cyst
- Fibrosis
- Fibroadenoma (simple)
- Columnar alteration (Simple)
- Apocrine metaplasia (simple)
- Mild ductal hyperplasia
- Approximately 30% of total are classifed as proliferative disease(PD) with relative cancer risk of 1.7, 2.1 times
- Usual ductal hyperplasia
- Sclerosing adenosis
- Columnar hyperplasia
- papilloma
- Radical scar
- Approximately 5% to 8% of the rest regarded to PD with atypia with relative cancer risk more than 4 times
- Atypical lobar hyperplasia
- Lobular carcinoma in situ
- Atypical ductal hyperplasia
- Unclear risk
- Mucocele like tumor
- Apocrine atypia
- Secretory atypia
Classification of benign breast lesion regarding to histological region:
- Terminal and lobular ducts
- Acinar distention
- Cyst
- Intralobular connective tissue proliferation
- Sclerosing adenosis
- Fibroadenoma
- Phyllodes tumor
- Hamartoma
- Epithelial changes in terminal duct lobaular units (TDLU)
- Apocrine metaplasia
- Ductal and lobular hyperplasia, usual and typical
- Papillomatosis
- Intracystic papilloma
- Acinar distention
- Ductal system
References
- ↑ Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K; et al. (2005). "Benign breast disease and the risk of breast cancer". N Engl J Med. 353 (3): 229–37. doi:10.1056/NEJMoa044383. PMID 16034008.