Scoliosis other imaging findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rohan A. Bhimani, M.B.B.S., D.N.B., M.Ch.[2]

Overview

Technetium 99m bone scan and 18F-fluoride positron emission tomography (PET) scan may be helpful in the diagnosis of the cases of persistent back pain with scoliosis, with negative findings on plain radiographs, CT, and/or MRI. 68Ga-citrate an emerging, generator-based tracer has shown promising results in pilot studies.

Other Imaging Findings

PET/PET CT

Thoracic Endplate Osteomyeltis with discitis. Source: Case courtesy of Dr Chris O'Donnell, Radiopaedia.org, rID: 18272

(MRI) to image the spine.

  • However, the presence of orthopedic hardware raises concerns about attenuation artifacts, and sites of increased 18F-fluoride uptake should be confirmed on PET images reconstructed without attenuation correction.






Bone Scan

68Ga-Citrate

  • 68Ga-citrate an emerging, generator-based tracer has shown promising results in pilot studies, where infection has been implicated as a cause for scoliosis.[4][5]

[6]

References

  1. Grant FD (2014). "¹⁸F-fluoride PET and PET/CT in children and young adults". PET Clin. 9 (3): 287–97. doi:10.1016/j.cpet.2014.03.004. PMID 25030392.
  2. Taniguchi Y, Takahashi M, Matsudaira K, Oka H, Momose T (2016). "Potential use of (18)F-FDG-PET/CT to visualize hypermetabolism associated with muscle pain in patients with adult spinal deformity: a case report". Skeletal Radiol. 45 (11): 1577–81. doi:10.1007/s00256-016-2464-x. PMID 27562570.
  3. Hospach T, Langendoerfer M, von Kalle T, Maier J, Dannecker GE (2010). "Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate". Eur J Pediatr. 169 (9): 1105–11. doi:10.1007/s00431-010-1188-5. PMID 20339868.
  4. Nanni C, Errani C, Boriani L, Fantini L, Ambrosini V, Boschi S; et al. (2010). "68Ga-citrate PET/CT for evaluating patients with infections of the bone: preliminary results". J Nucl Med. 51 (12): 1932–6. doi:10.2967/jnumed.110.080184. PMID 21078801.
  5. Hadjipavlou AG, Cesani-Vazquez F, Villaneuva-Meyer J, Mader JT, Necessary JT, Crow W; et al. (1998). "The effectiveness of gallium citrate Ga 67 radionuclide imaging in vertebral osteomyelitis revisited". Am J Orthop (Belle Mead NJ). 27 (3): 179–83. PMID 9544359.
  6. Gratz S, Dörner J, Oestmann JW, Opitz M, Behr T, Meller J; et al. (2000). "67Ga-citrate and 99Tcm-MDP for estimating the severity of vertebral osteomyelitis". Nucl Med Commun. 21 (1): 111–20. PMID 10717911.

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