Enteropathy-associated T-cell lymphoma (patient information)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
What are the symptoms of Enteropathy-associated T-cell lymphoma?
Some of the symptoms of EATL include:
- Abdominal pain
- Diarrhea
- Unexpected weight loss
- Skin lesion
- Fever
- Night sweat
What causes Enteropathy-associated T-cell lymphoma?
There aren't sufficient studies regarding causes of Enteropathy-associated T-cell lymphoma, in other words, it's not known causes for this disease.
Who is at highest risk?
- Enteropathy-associated T cell lymphoma type I is more common among those diagnosed with celiac disease, however, type II can be seen in those without celiac disease[1]
- There is a male gender predilection.
Diagnosis
- It is recommended that patients coming with malabsorption symptoms such as diarrhea, unintentional weight loss, or painless swollen lymph nodes, night sweats, fever should be considered for the diagnosis of gastrointestinal lymphoma, extensive workup must be done such as complete blood count, imaging studies such as abdominal CT scan, final diagnosis needs endoscopy and biopsy of the specimen.
When to seek urgent medical care?
- Patients who suffer from malabsorption, unintentional weight loss, diarrhea, fever, night sweat must visit their primary physicians in order to have an extensive workup done and rule out intestinal lymphoma.
Treatment options
- Unfortunately tumor is very aggressive in nature and mainstay therapy is supportive, chemotherapy and surgery or stem cell transplant can be used but prognosis is very poor.
Where to find medical care for Enteropathy-associated T-cell lymphoma?
Prevention of Enteropathy-associated T-cell lymphoma
- There is no prevention methods for enteropathy-associated T cell lymphoma.
What to expect (Outlook/Prognosis)?
- Prognosis is very poor and the tumor is very aggressive in nature.
Possible complications
- some of the possible complications of enteropathy-associated T cell lymphoma include:
- Small bowel obstruction
- Perforation
- Intussusception
Source
- ↑ Sieniawski, M.; Angamuthu, N.; Boyd, K.; Chasty, R.; Davies, J.; Forsyth, P.; Jack, F.; Lyons, S.; Mounter, P.; Revell, P.; Proctor, S. J.; Lennard, A. L. (2010). "Evaluation of enteropathy-associated T-cell lymphoma comparing standard therapies with a novel regimen including autologous stem cell transplantation". Blood. 115 (18): 3664–3670. doi:10.1182/blood-2009-07-231324. ISSN 0006-4971.