Breast lumps classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]
Overview
Breast lumps may be classified according to epithelial hyperplasia into 3 subtypes: non-proliferative, proliferative disease and proliferative disease without atypia.
Breast lumps may be classified into 3 subtypes based on histological regions: lobular region, ductal region, different origins.
Classification
Classification of breast lumps based on epithelial hyperplasia[1]
- Approximately 65% of all benign breast disease considered as nonproliferative (NP)with relative cancer risk of 1.2, 1.4 times:
- Simple cyst
- Fibrosis
- Fibroadenoma (simple)
- Columnar alteration (Simple)
- Apocrine metaplasia (simple)
- Mild ductal hyperplasia
- Approximately 30% of total are classified as (PD) with relative cancer risk of 1.7, 2.1 times
- Usual ductal hyperplasia
- Sclerosing adenosis
- Columnar hyperplasia
- papilloma
- Radical scar
- Approximately 5% to 8% of the rest regarded to PD with atypia with relative cancer risk more than 4 times
- Atypical lobar hyperplasia
- Lobular carcinoma in situ
- Atypical ductal hyperplasia
- Unclear risk
Classification of benign breast lesion regarding to histologist region:[2]
- Terminal and lobular ducts
- Acinar distention
- Intralobular connective tissue proliferation
- Sclerosing adenosis
- Fibroadenoma
- Phyllodes tumor
- Hamartoma
- Epithelial changes in terminal duct lobular units (TDLU)
- Apocrine metaplasia
- Ductal and lobular hyperplasia, usual and typical
- Papillomatosis
- Intracystic papilloma
- Ductal system
- Lesion of different origin
- Fatty tissue lesion
- Lipoma
- Liponecrosis
- Fibrous tissue lesions
- Focal fibrosis
- Diabetic mastopathy
- Pseudoangiomatous stromal hyperplasia (PASH)
- Myofibroblastoma
- Vascular origin
- Inflammatory origin
- Mastitis/abscess
- Tuberculosis and sarcoidosis
- Foreign body granuloma and siliconoma
- Lymph node origin
- Inflammatory lymph nodes
- Fatty tissue lesion
References
- ↑ Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K; et al. (2005). "Benign breast disease and the risk of breast cancer". N Engl J Med. 353 (3): 229–37. doi:10.1056/NEJMoa044383. PMID 16034008.
- ↑ Lanyi, M (2003). Mammography : diagnosis and pathological analysis. Berlin New York: Springer-Verlag. ISBN 9783540441137.