Hemolytic-uremic syndrome diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [3], Anila Hussain, MD [4]
Overview
There is no single diagnostic study of choice for the diagnosis of HUS.
Diagnostic Study of Choice
There is no single diagnostic study of choice for the diagnosis of hemolytic uremic syndrome (HUS), but HUS can be diagnosed based on clinical presentation along with lab findings of microangiopathic hemolytic anemia with low hemoglobin (Hb), low haptoglobin, high reticulocyte count and negative coombs test, thrombocytopenia with platelets less than 60,000 along with abnormal renal function as indicated with high blood urea nitrogen (BUN) and creatinine and electrolyte abnormalities. A diagnosis of atypical hemolytic uremic syndrome requires testing for antibodies to complement factors H and I or testing for mutations in complement proteins or receptors.