Hepatocellular adenoma epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]
Overview
The hepatocellular adenoma is more common in women in western countries where they are exposed to higher doses of oral contraceptives. The estimated incidence is 3 per 1,000,000/year and is 3 to 4 per 100,000 with long term oral contraceptive use. It is more common in women of childbearing age who take oral contraceptives and can rarely occur in men who take long term anabolic androgenic steroids.
Epidemiology and demographics
- The hepatocellular adenoma is more common in women in western countries, where they are exposed to higher doses of oral contraceptives.[1]
- Hepatocellular adenoma is rare in regions where oral contraception is not widely used, such as asia.
- The prevalence of hepatocellular adenoma was increased in 1970s following the introduction of oral contraception in western countries.[2]
Incidence
- The estimated incidence of hepatocellular adenoma is 3 per 1,000,000/year.[3][4][5]
- The annual incidence is substantially higher with long term oral contraceptive use, estimated at 3 to 4 per 100,000, but may be less with newer oral contraceptives.
Age
- The hepatocellular adenoma is more common in woman of childbearing age who take oral contraceptives.[6]
Gender
- The hepatocellular adenoma is more common in women of childbearing age who take oral contraceptives, but can also occur rarely in men with long term anabolic androgenic steroids use.
References
- ↑ Nault, Jean-Charles; Paradis, Valérie; Cherqui, Daniel; Vilgrain, Valérie; Zucman-Rossi, Jessica (2017). "Molecular classification of hepatocellular adenoma in clinical practice". Journal of Hepatology. 67 (5): 1074–1083. doi:10.1016/j.jhep.2017.07.009. ISSN 0168-8278.
- ↑ Védie, Anne-Laure; Sutter, Olivier; Ziol, Marianne; Nault, Jean-Charles (2018). "Molecular classification of hepatocellular adenomas: impact on clinical practice". Hepatic Oncology. 5 (1): HEP04. doi:10.2217/hep-2017-0023. ISSN 2045-0923.
- ↑ Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
- ↑ Nault, Jean-Charles; Couchy, Gabrielle; Balabaud, Charles; Morcrette, Guillaume; Caruso, Stefano; Blanc, Jean-Frederic; Bacq, Yannick; Calderaro, Julien; Paradis, Valérie; Ramos, Jeanne; Scoazec, Jean-Yves; Gnemmi, Viviane; Sturm, Nathalie; Guettier, Catherine; Fabre, Monique; Savier, Eric; Chiche, Laurence; Labrune, Philippe; Selves, Janick; Wendum, Dominique; Pilati, Camilla; Laurent, Alexis; De Muret, Anne; Le Bail, Brigitte; Rebouissou, Sandra; Imbeaud, Sandrine; Bioulac-Sage, Paulette; Letouzé, Eric; Zucman-Rossi, Jessica; Laurent, Christophe; Saric, Jean; Frulio, Nora; Castain, Claire; Dujardin, Fanny; Benchellal, Zin; Bourlier, Pascal; Azoulay, Daniel; Luciani, Alain; Pageaux, Georges-Philippe; Fabre, Jean-Michel; Vilgrain, Valerie; Belghiti, Jacques; Bancel, Brigitte; Boleslawski, Emmanuel; Letoublon, Christophe; Vaillant, Jean Christophe; Prévôt, Sophie; Castaing, Denis; Jacquemin, Emmanuel; Peron, Jean Marie; Quaglia, Alberto; Paye, François; Terraciano, Luigi; Mazzaferro, Vincenzo; Saint Paul, Marie Christine; Terris, Benoit (2017). "Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation". Gastroenterology. 152 (4): 880–894.e6. doi:10.1053/j.gastro.2016.11.042. ISSN 0016-5085.
- ↑ J. B. Rooks, H. W. Ory, K. G. Ishak, L. T. Strauss, J. R. Greenspan, A. P. Hill & C. W. Jr Tyler (1979). "Epidemiology of hepatocellular adenoma. The role of oral contraceptive use". JAMA. 242 (7): 644–648. PMID 221698. Unknown parameter
|month=ignored (help) - ↑ L. A. Heinemann, A. Weimann, G. Gerken, C. Thiel, M. Schlaud & T. DoMinh (1998). "Modern oral contraceptive use and benign liver tumors: the German Benign Liver Tumor Case-Control Study". The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 3 (4): 194–200. PMID 10036602. Unknown parameter
|month=ignored (help)