Splenic marginal zone lymphoma differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Splenic marginal zone lymphoma must be differentiated from other diseases such as chronic lymphocytic leukemia, follicular lymphoma, and mantle cell lymphoma.

Differential Diagnosis

Splenic marginal zone lymphoma must be differentiated from other diseases such as:

• Chronic lymphocytic leukemia
• Follicular lymphoma
• Mantle cell lymphoma

Differential Diagnosis	Cytogenetics	Morphology	Immunophenotype
Splenic marginal zone lymphoma	Negative	Negative	Negative
Chronic lymphocytic leukemia	Positive	Negative	Negative
Follicular lymphoma	Negative	Positive	Positive
Splenic Diffuse red Pulp lymphoma	Positive	Negative	Negative
Hairy Celll Leukemia variant	Negative	Positive	Positive
Mantle cell lymphoma	Positive	Negative	Positive
Hairy cell leukeia	Negative	Positive	Positive
Lymphoplasmocytic lymphoma	Positive	Negative	Positive