SAM domain, SH3 domain and nuclear localization signals 1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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Wikidata
View/Edit Human

SAM domain, SH3 domain and nuclear localization signals 1 is a protein that in humans is encoded by the SAMSN1 gene.

Function

SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).

Further reading

• Zhu YX, Benn S, Li ZH, Wei E, Masih-Khan E, Trieu Y, Bali M, McGlade CJ, Claudio JO, Stewart AK (2004). "The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades". J. Exp. Med. 200 (6): 737–47. doi:10.1084/jem.20031816. PMC 2211965. PMID 15381729.
• Yamada H, Yanagisawa K, Tokumaru S, Taguchi A, Nimura Y, Osada H, Nagino M, Takahashi T (2008). "Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer". Genes Chromosomes Cancer. 47 (9): 810–8. doi:10.1002/gcc.20582. PMID 18523997.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Brandt S, Ellwanger K, Beuter-Gunia C, Schuster M, Hausser A, Schmitz I, Beer-Hammer S (2010). "SLy2 targets the nuclear SAP30/HDAC1 complex". Int. J. Biochem. Cell Biol. 42 (9): 1472–81. doi:10.1016/j.biocel.2010.05.004. PMID 20478393.
• von Holleben M, Gohla A, Janssen KP, Iritani BM, Beer-Hammer S (2011). "Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading". J. Biol. Chem. 286 (15): 13489–501. doi:10.1074/jbc.M110.155184. PMC 3075695. PMID 21296879.
• Yan Y, Zhang L, Xu T, Zhou J, Qin R, Chen C, Zou Y, Fu D, Hu G, Chen J, Lu Y (2013). "SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme". PLoS ONE. 8 (11): e81905. doi:10.1371/journal.pone.0081905. PMC 3838348. PMID 24278465.
• Noll JE, Hewett DR, Williams SA, Vandyke K, Kok C, To LB, Zannettino AC (2014). "SAMSN1 is a tumor suppressor gene in multiple myeloma". Neoplasia. 16 (7): 572–85. doi:10.1016/j.neo.2014.07.002. PMC 4198825. PMID 25117979.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.