Burkitt's lymphoma staging

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2], Kamal Akbar, M.D.[3]

Overview

According to the Murphy staging system, there are four stages of Burkitt's lymphoma based on the number of nodes involved and the extra nodal spread.

Staging

According to the Murphy staging system, there are four stages of Burkitt's lymphoma based on the number of nodes involved and the extra nodal spread.

Staging for Burkitt's lymphoma is provided in the following table:

Murphy staging system

Stage	Features
Stage I	Single nodal or extra nodal site involvement excluding mediastinum or abdomen
Stage II	Single extra nodal tumor with regional nodal involvement Two extra nodal tumors on one side of diaphragm Primary gastrointestinal tumor with or without associated mesenteric nodes Two or more nodal areas on one side of diaphragm
Stage IIR	Completely resected intra-abdominal disease
Stage III	Two single extra nodal tumors on opposite sides of diaphragm All primary intra thoracic tumors All paraspinal or epidural tumors All extensive primary intra-abdominal disease Two or more nodal areas on opposite sides of diaphragm
Stage IIIA	Localized, non-resectable abdominal disease
Stage IIIB	Widespread multi organ abdominal disease
Stage IV	Initial CNS or bone marrow involvement (< 25%)

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