MAP4K5

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the MAP4K5 gene.[1][2][3]

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[3]

Interactions

MAP4K5 has been shown to interact with CRKL[4] and TRAF2.[5]

References

  1. Tung RM, Blenis J (March 1997). "A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase". Oncogene. 14 (6): 653–9. doi:10.1038/sj.onc.1200877. PMID 9038372.
  2. Schultz SJ, Nigg EA (February 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
  3. 3.0 3.1 "Entrez Gene: MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5".
  4. Shi, C S; Tuscano J; Kehrl J H (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation". Blood. UNITED STATES. 95 (3): 776–82. ISSN 0006-4971. PMID 10648385.
  5. Shi, C S; Leonardi A; Kyriakis J; Siebenlist U; Kehrl J H (September 1999). "TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related". J. Immunol. UNITED STATES. 163 (6): 3279–85. ISSN 0022-1767. PMID 10477597.

Further reading