INSM1

Revision as of 04:30, 6 September 2018 by en>Boghog (removed no longer needed PBB controls and templates consistent citation formatting; removed further reading citations not specific to this gene)
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.[1][2][3]

Function

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.[3] [4]

Interactions

INSM1 has been shown to interact with SORBS1.[5]

References

  1. Lan MS, Li Q, Lu J, Modi WS, Notkins AL (May 1994). "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1". The Journal of Biological Chemistry. 269 (19): 14170–4. PMID 8188699.
  2. Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS (July 2006). "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases". The Biochemical Journal. 397 (1): 169–77. doi:10.1042/BJ20051669. PMC 1479746. PMID 16569215.
  3. 3.0 3.1 "Entrez Gene: INSM1 insulinoma-associated 1".
  4. Mukhopadhyay S, Dermawan JK, Lanigan CP, Farver CF (August 2018). "Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections". Modern Pathology. Epub ahead of print. doi:10.1038/s41379-018-0122-7. PMID 30154579.
  5. Xie J, Cai T, Zhang H, Lan MS, Notkins AL (July 2002). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics. 80 (1): 54–61. doi:10.1006/geno.2002.6800. PMC 1237014. PMID 12079283.

Further reading