MPGES-1

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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Microsomal prostaglandin E synthase-1 (mPGES-1)[1][2] or Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene.[3][4][5]

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis.

Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.[5]

See also

References

  1. Jakobsson PJ, Thorén S, Morgenstern R, et al. (1989). "Identification of human prostaglandin E synthase: a microsomal glutathione-dependent, inducible enzyme, constituting a potential novel drug target". Proc Natl Acad Sci USA. 96: 7220–7225. doi:10.1073/pnas.96.13.7220. PMC 22058. PMID 10377395.
  2. Hui-Hua Chang; Emmanuelle J Meuillet (2011). "Identification and development of mPGES-1 inhibitors: where we are at?". Future Med Chem. 3 (15): 1909–1934. doi:10.4155/fmc.11.136. PMC 3232027. PMID 22023034.
  3. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. doi:10.1038/38525. PMID 9305847.
  4. Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B (May 1999). "Common structural features of MAPEG -- a widespread superfamily of membrane-associated proteins with highly divergent functions in eicosanoid and glutathione metabolism". Protein Sci. 8 (3): 689–92. doi:10.1110/ps.8.3.689. PMC 2144274. PMID 10091672.
  5. 5.0 5.1 "Entrez Gene: PTGES prostaglandin E synthase".

Further reading