TNKS2

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.

Interactions

TNKS2 has been shown to interact with GRB14, TERF1 and Cystinyl aminopeptidase.

Further reading

• Monz D, Munnia A, Comtesse N, et al. (2001). "Novel tankyrase-related gene detected with meningioma-specific sera". Clin. Cancer Res. 7 (1): 113–9. PMID 11205898.
• Lyons RJ, Deane R, Lynch DK, et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. 276 (20): 17172–80. doi:10.1074/jbc.M009756200. PMID 11278563.
• Kuimov AN, Kuprash DV, Petrov VN, et al. (2001). "Cloning and characterization of TNKL, a member of tankyrase gene family". Genes Immun. 2 (1): 52–5. doi:10.1038/sj.gene.6363722. PMID 11294570.
• Kaminker PG, Kim SH, Taylor RD, et al. (2001). "TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression". J. Biol. Chem. 276 (38): 35891–9. doi:10.1074/jbc.M105968200. PMID 11454873.
• Cook BD, Dynek JN, Chang W, et al. (2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. 22 (1): 332–42. doi:10.1128/MCB.22.1.332-342.2002. PMC 134233. PMID 11739745.
• Sbodio JI, Lodish HF, Chi NW (2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. PMC 1222327. PMID 11802774.
• Seimiya H, Smith S (2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)". J. Biol. Chem. 277 (16): 14116–26. doi:10.1074/jbc.M112266200. PMID 11854288.
• Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Deng Z, Atanasiu C, Zhao K, et al. (2005). "Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1". J. Virol. 79 (8): 4640–50. doi:10.1128/JVI.79.8.4640-4650.2005. PMC 1069541. PMID 15795250.
• Sidorova N, Zavalishina L, Kurchashova S, et al. (2006). "Immunohistochemical detection of tankyrase 2 in human breast tumors and normal renal tissue". Cell Tissue Res. 323 (1): 137–45. doi:10.1007/s00441-005-0053-8. PMID 16151859.