ST8SIA6

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene.

Function

Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).

Further reading

• Avril T, North SJ, Haslam SM, Willison HJ, Crocker PR (2006). "Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression". J. Leukoc. Biol. 80 (4): 787–96. doi:10.1189/jlb.1005559. PMID 16857734.
• Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37: 210–270. doi:10.1002/med.21407.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.