DENR (gene)

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Density regulated re-initiation and release factor (DENR) is a protein that in humans is encoded by the DENR gene.

Function

This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing the HER2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF2 and the initiator Met-tRNA_i^Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008].

See also

• Eukaryotic initiation factors
• Eukaryotic translation

Further reading

• Mazan-Mamczarz K, Gartenhaus RB (2007). "Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1". Cancer Genomics Proteomics. 4 (3): 233–9. PMID 17878526.
• Lomakin IB, Stolboushkina EA, Vaidya AT, Zhao C, Garber MB, Dmitriev SE, Steitz TA (2017). "Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1". Cell Rep. 20 (3): 521–528. doi:10.1016/j.celrep.2017.06.025. PMC 5551485. PMID 28723557.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.