Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B gene .
[1]
Regulation during differentation KDM6B was found to be expressional increased during cardiac and endothelial differentation of murine embryonic stem cells.[2]
Small molecule inhibition A small molecule inhibition (GSK-J1) has been developed to inhibit jumonji domain of KDM6 histone demethylase family to modulate proinflammatory response in macrophage .[3]
References
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"Entrez Gene: Lysine demethylase 6B" . Retrieved 2016-04-09 .
↑ Boeckel, Jes-Niels; Derlet, Anja; Glaser, Simone F.; Luczak, Annika; Lucas, Tina; Heumüller, Andreas W.; Krüger, Marcus; Zehendner, Christoph M.; Kaluza, David (July 2016). "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells". Arteriosclerosis, Thrombosis, and Vascular Biology . 36 (7): 1425–1433. doi :10.1161/ATVBAHA.116.307695 . ISSN 1524-4636 . PMID 27199445 . ↑ Kruidenier, Laurens; Chung, Chun-wa; Cheng, Zhongjun; Liddle, John; Che, KaHing; Joberty, Gerard; Bantscheff, Marcus; Bountra, Chas; Bridges, Angela (2012-08-16). "A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response" . Nature . 488 (7411): 404–408. doi :10.1038/nature11262 . ISSN 1476-4687 . PMC 4691848 PMID 22842901 .
Further reading
Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K (2007). "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development". Nature . 449 (7163): 731–4. doi :10.1038/nature06145 . PMID 17713478 .
