Chromosome 19 open reading frame 33

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Chromosome 19 open reading frame 33 is a protein that in humans is encoded by the C19orf33 gene.

Function

The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].

Further reading

• Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M (October 2001). "Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes". Biochem. Biophys. Res. Commun. 288 (2): 390–9. doi:10.1006/bbrc.2001.5767. PMID 11606055.
• Kim JK, An HJ, Kim NK, Ahn JY, Kim KS, Kang YJ, Ko JJ, Oh D, Lee C, Kim SJ, Cha KY (2003). "IMUP-1 and IMUP-2 genes are up-regulated in human ovarian epithelial tumors". Anticancer Res. 23 (6C): 4709–13. PMID 14981917.
• Naganuma S, Itoh H, Uchiyama S, Nagaike K, Tanaka H, Akiyama Y, Chijiiwa K, Kataoka H (March 2006). "Nuclear translocation of H2RSP is impaired in regenerating intestinal epithelial cells of murine colitis model". Virchows Arch. 448 (3): 354–60. doi:10.1007/s00428-005-0064-6. PMID 16189703.
• Betsunoh H, Mukai S, Akiyama Y, Fukushima T, Minamiguchi N, Hasui Y, Osada Y, Kataoka H (April 2007). "Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma". Cancer Sci. 98 (4): 491–8. doi:10.1111/j.1349-7006.2007.00412.x. PMID 17309599.
• Kim SJ, An HJ, Kim HJ, Jungs HM, Lee S, Ko JJ, Kim IH, Sakuragi N, Kim JK (2008). "Imup-1 and imup-2 overexpression in endometrial carcinoma in Korean and Japanese populations". Anticancer Res. 28 (2A): 865–71. PMID 18507030.
• Jeon SY, Lee HJ, Park JM, Jung HM, Yoo JK, Lee HJ, Lee JS, Cha DH, Kim JK, Kim GJ (May 2010). "Increased immortalization-upregulated protein 2 (IMUP-2) by hypoxia induces apoptosis of the trophoblast and pre-eclampsia". J. Cell. Biochem. 110 (2): 522–30. doi:10.1002/jcb.22568. PMID 20432246.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.