SDPR

Revision as of 11:38, 4 March 2018 by imported>Rjwilmsi (→‎top: Journal cites:, added 1 PMC)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cavin-2 or Serum deprivation-response protein (SDPR) is a protein that in humans is encoded by the SDPR gene.[1][2][3] Cavin-2 is highly expressed in a variety of human endothelial cells.[4]

This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein has also been shown to be a substrate for protein kinase C (PKC) phosphorylation.[3]

Function

Cavin-2 is required for blood vessel formation (angiogenesis) in humans and zebrafish and required also for the endothelial cell proliferation, migration and invasion in humans.[4] Cavin-2 plays an important role in endothelial cell maintenance by regulating eNOS activity.[4] Cavin-2 controls the generation of nitric oxide (NO) in human endothelial cells by controlling the activity and stability of the protein endothelial nitric-oxide synthase (eNOS).[4]

Secretion

Cavin-2 is highly secreted from human endothelial cells (HUVEC), they are secreted through endothelial microparticles (EMPs) but not exosomes and is required for EMP biogenesis.[4]

Clinical significance

SDPR is shown to act as a metastasis suppressor by xenograft studies utilizing breast cancer cell lines.[5] SDPR may elicit its metastasis suppressor function by directly interacting with ERK and limiting its pro-survival role.[5] Moreover, it is suggested that SDPR is silenced during breast cancer progression by promoter DNA methylation.[5] Metastasis suppressor role of SDPR may go beyond breast cancer since tumor samples from bladder, colorectal, lung, pancreatic, and ovarian cancers as well as sarcomas also exhibited loss of SDPR expression.[5]

References

  1. Gustincich S, Vatta P, Goruppi S, Wolf M, Saccone S, Della Valle G, Baggiolini M, Schneider C (Jun 1999). "The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein". Genomics. 57 (1): 120–9. doi:10.1006/geno.1998.5733. PMID 10191091.
  2. Gustincich S, Schneider C (Dec 1993). "Serum deprivation response gene is induced by serum starvation but not by contact inhibition". Cell Growth Differ. 4 (9): 753–60. PMID 8241023.
  3. 3.0 3.1 "Entrez Gene: SDPR serum deprivation response (phosphatidylserine binding protein)".
  4. 4.0 4.1 4.2 4.3 4.4 Boopathy GT, Kulkarni M, Ho SY, Boey A, Chua EW, Barathi VA, Carney TJ, Wang X, Hong W (2017). "Cavin-2 regulates the activity and stability of endothelial nitric oxide synthase (eNOS) in angiogenesis". The Journal of Biological Chemistry. 292: 17760–17776. doi:10.1074/jbc.M117.794743. PMC 5663877. PMID 28912276.
  5. 5.0 5.1 5.2 5.3 Sait Ozturk; Panagiotis Papageorgis; Chen Khuan Wong; Arthur W. Lambert; Hamid M. Abdolmaleky; Arunthathi Thiagalingam; Herbert T. Cohen & Sam Thiagalingam (Jan 2016). "SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis". PNAS. 113: 638–643. doi:10.1073/pnas.1514663113. PMC 4725521. PMID 26739564.

Further reading