Revision as of 06:27, 23 August 2018 by imported>ProteinBoxBot(←Created page with '{{Infobox_gene}} '''ST6 beta-galactoside alpha-2,6-sialyltransferase 2''' is a protein that in humans is encoded by the ST6GAL2 gene. <ref name="entrez"...')
ST6 beta-galactoside alpha-2,6-sialyltransferase 2 is a protein that in humans is encoded by the ST6GAL2 gene.
[1]
Function
This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].
Krzewinski-Recchi MA, Julien S, Juliant S, Teintenier-Lelièvre M, Samyn-Petit B, Montiel MD, Mir AM, Cerutti M, Harduin-Lepers A, Delannoy P (March 2003). "Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II". Eur. J. Biochem. 270 (5): 950–61. PMID12603328.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (August 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID19240061.
Lehoux S, Groux-Degroote S, Cazet A, Dhaenens CM, Maurage CA, Caillet-Boudin ML, Delannoy P, Krzewinski-Recchi MA (January 2010). "Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells". Glycoconj. J. 27 (1): 99–114. doi:10.1007/s10719-009-9260-y. PMID19768537.
Ikeda M, Tomita Y, Mouri A, Koga M, Okochi T, Yoshimura R, Yamanouchi Y, Kinoshita Y, Hashimoto R, Williams HJ, Takeda M, Nakamura J, Nabeshima T, Owen MJ, O'Donovan MC, Honda H, Arinami T, Ozaki N, Iwata N (February 2010). "Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches". Biol. Psychiatry. 67 (3): 263–9. doi:10.1016/j.biopsych.2009.08.030. PMID19850283.
