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Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1gene.[1][2][3]
A single nucleotide polymorphism (rs17070145) [4] in the gene has been associated with human memory performance in one 2006 study.[5] While no significant support for KIBRA's association with memory was found in a 2008 study with 584 subjects,[6] the original 2006 study was replicated in a smaller sample of an elderly population in 2008.[7] A subsequent study in 2009 in two large UK samples indicated that KIBRA is specifically associated with forgetting of non-semantic material.[8]
KIBRA has at least 10 interaction partners, including synaptopodin, PKCζ and Dendrin, most of which modify synaptic plasticity.
For instance, Dendrin is a post-synaptic protein with expression regulated by sleep deprivation.[10]KIBRA has been shown to interact with Protein kinase Mζ.[11]
References
↑Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID10048485.
↑Kremerskothen J, Plaas C, Büther K, Finger I, Veltel S, Matanis T, Liedtke T, Barnekow A (Jan 2003). "Characterization of KIBRA, a novel WW domain-containing protein". Biochem Biophys Res Commun. 300 (4): 862–7. doi:10.1016/S0006-291X(02)02945-5. PMID12559952.
↑Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A, Coluccia D, Hänggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ (October 2006). "Common Kibra alleles are associated with human memory performance". Science. 314 (5798): 475–8. doi:10.1126/science.1129837. PMID17053149.
↑Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, Gumbs CE, Giegling I, Möller HJ, Francks C, Muglia P, Roses A, Gibson G, Weale ME, Rujescu D, Goldstein DB (July 2008). "Failure to replicate effect of Kibra on human memory in two large cohorts of European origin". American Journal of Medical Genetics. 147B (5): 667–8. doi:10.1002/ajmg.b.30658. PMID18205171.
↑Schaper K, Kolsch H, Popp J, Wagner M, Jessen F (July 2008). "KIBRA gene variants are associated with episodic memory in healthy elderly". Neurobiol. Aging. 29 (7): 1123–5. doi:10.1016/j.neurobiolaging.2007.02.001. PMID17353070.
↑Bates TC, Price JF, Harris SE, Marioni RE, Fowkes FG, Stewart MC, Murray GD, Whalley LJ, Starr JM, Deary IJ (July 2009). "Association of KIBRA and memory". Neurosci. Lett. 458 (3): 140–3. doi:10.1016/j.neulet.2009.04.050. PMID19397951.
↑Büther K, Plaas C, Barnekow A, Kremerskothen J (May 2004). "KIBRA is a novel substrate for protein kinase Czeta". Biochem. Biophys. Res. Commun. 317 (3): 703–7. doi:10.1016/j.bbrc.2004.03.107. PMID15081397.
Further reading
Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, Gumbs CE, Giegling I, Möller HJ, Francks C, Muglia P, Roses A, Gibson G, Weale ME, Rujescu D, Goldstein DB (2008). "Failure to replicate effect of kibra on human memory in two large cohorts of European origin". American Journal of Medical Genetics. 147B (5): 667–8. doi:10.1002/ajmg.b.30658. PMID18205171.
Almeida OP, Schwab SG, Lautenschlager NT, Morar B, Greenop KR, Flicker L, Wildenauer D (2008). "KIBRA Genetic Polymorphism Influences Episodic Memory in Later Life, but Does Not Increase the Risk of Mild Cognitive Impairment". Journal of Cellular and Molecular Medicine. 12 (5A): 1672–6. doi:10.1111/j.1582-4934.2008.00229.x. PMID18194457.
Rodríguez-Rodríguez E, Infante J, Llorca J, Mateo I, Sánchez-Quintana C, García-Gorostiaga I, Sánchez-Juan P, Berciano J, Combarros O (2009). "Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk". Neurobiol. Aging. 30 (2): 322–4. doi:10.1016/j.neurobiolaging.2007.07.003. PMID17707552.
Schaper K, Kolsch H, Popp J, Wagner M, Jessen F (2008). "KIBRA gene variants are associated with episodic memory in healthy elderly". Neurobiol. Aging. 29 (7): 1123–5. doi:10.1016/j.neurobiolaging.2007.02.001. PMID17353070.
Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A, Coluccia D, Hänggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ (2006). "Common Kibra alleles are associated with human memory performance". Science. 314 (5798): 475–8. doi:10.1126/science.1129837. PMID17053149.
Rayala SK, den Hollander P, Manavathi B, Talukder AH, Song C, Peng S, Barnekow A, Kremerskothen J, Kumar R (2006). "Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells". J. Biol. Chem. 281 (28): 19092–9. doi:10.1074/jbc.M600021200. PMID16684779.
Büther K, Plaas C, Barnekow A, Kremerskothen J (2004). "KIBRA is a novel substrate for protein kinase Czeta". Biochem. Biophys. Res. Commun. 317 (3): 703–7. doi:10.1016/j.bbrc.2004.03.107. PMID15081397.