CLPTM1L

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (protein)

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Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene.[1][2] CRR9p is associated with cisplatin-induced apoptosis.[2] CLPTM1L, which lies within a cancer susceptibility locus on chromosome 5 (5p15.33), has been found to be commonly over-expressed in lung tumors and to confer resistance to apoptosis caused by genotoxic agents in association with up-regulation of the anti-apoptotic protein, Bcl-xL.[3] Inhibition of CLPTM1L has been shown to inhibit oncogenic transformation and tumorigenesis caused by the KRas oncogene partially through the PI3K/Akt survival signaling axis.[4]

See also

References

  1. "Entrez Gene: CLPTM1-like".
  2. 2.0 2.1 Yamamoto K, Okamoto A, Isonishi S, Ochiai K, Ohtake Y (Feb 2001). "A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis". Biochem Biophys Res Commun. 280 (4): 1148–54. doi:10.1006/bbrc.2001.4250. PMID 11162647.
  3. James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M (2012). "Functional Characterization of CLPTM1L as a Lung". PLoS ONE. 7 (6): 63116. doi:10.1371/journal.pone.0036116. PMC 3366984. PMID 22675468.
  4. James MA, Vikis HG, Tate E, Rymaszewski AL, et al. (2014). "CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis". Cancer Res. 74 (4): 1116–27. doi:10.1158/0008-5472.CAN-13-1617. PMID 24366883.

External links

Further reading