NDFIP1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene.

Function

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008].

Further reading

• Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS (2008). "Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins". J. Biol. Chem. 283 (47): 32621–7. doi:10.1074/jbc.M804120200. PMID 18819914.
• Mund T, Pelham HR (2009). "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins". EMBO Rep. 10 (5): 501–7. doi:10.1038/embor.2009.30. PMC 2680872. PMID 19343052.
• Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS (2009). "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons". Proc. Natl. Acad. Sci. U.S.A. 106 (36): 15489–94. doi:10.1073/pnas.0904880106. PMC 2741278. PMID 19706893.
• Mund T, Pelham HR (2010). "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2". Proc. Natl. Acad. Sci. U.S.A. 107 (25): 11429–34. doi:10.1073/pnas.0911714107. PMC 2895104. PMID 20534535.
• Schieber C, Howitt J, Putz U, White JM, Parish CL, Donnelly PS, Tan SS (2011). "Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes". J. Biol. Chem. 286 (10): 8555–64. doi:10.1074/jbc.M110.203448. PMC 3048738. PMID 21187286.
• Wang Y, Tong X, Ye X (2012). "Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation". J. Immunol. 189 (11): 5304–13. doi:10.4049/jimmunol.1201445. PMID 23087404.
• Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS (2014). "Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels". PLoS ONE. 9 (1): e87119. doi:10.1371/journal.pone.0087119. PMC 3901732. PMID 24475238.
• Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS (2015). "Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response". J. Biol. Chem. 290 (11): 7141–50. doi:10.1074/jbc.M114.613687. PMC 4358134. PMID 25631046.
• Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y (2015). "Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells". Biochem. Biophys. Res. Commun. 465 (4): 851–6. doi:10.1016/j.bbrc.2015.08.099. PMID 26319551.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.