Revision as of 19:33, 16 February 2018 by imported>Boghog(removed no longer needed PBB controls and templates consistent citation formatting; removed further reading citations not specific to this gene; wikified)
Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type 1 receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.[3]
References
↑Henry J, Miller MM, Pontarotti P (June 1999). "Structure and evolution of the extended B7 family". Immunology Today. 20 (6): 285–8. doi:10.1016/S0167-5699(98)01418-2. PMID10354554.
↑Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN (May 1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Research. 7 (5): 441–56. doi:10.1101/gr.7.5.441. PMID9149941.
Cavaletto M, Giuffrida MG, Fortunato D, Gardano L, Dellavalle G, Napolitano L, Giunta C, Bertino E, Fabris C, Conti A (July 2002). "A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane". Proteomics. 2 (7): 850–6. doi:10.1002/1615-9861(200207)2:7<850::AID-PROT850>3.0.CO;2-C. PMID12124930.
Rhodes DA, Stammers M, Malcherek G, Beck S, Trowsdale J (February 2001). "The cluster of BTN genes in the extended major histocompatibility complex". Genomics. 71 (3): 351–62. doi:10.1006/geno.2000.6406. PMID11170752.
