Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene .[ 1]
Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans.[ 2] [ 3] atypical SLCs that was recently listed.[ 2]
UNC93A is closely related to Unc93B1 and MFSD11 .[ 4] [ 5]
UNC93A is affected by amino acid deprivation in cell cortex cultures[ 3] [ 4] in vivo samples.[ 4]
It is expressed in neurons, with staining close to the plasma membrane.[ 4]
Read also [ 6] [ 7]
References
↑
"Entrez Gene: Unc-93 homolog A (C. elegans)" .
↑ 2.0 2.1 Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences . 38 (3): 305–315. doi :10.1016/j.tips.2016.11.008 . PMID 27939446 . ↑ 3.0 3.1 Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression" . Open Biology . 7 (9): 170142. doi :10.1098/rsob.170142 . PMC 5627054 PMID 28878041 . ↑ 4.0 4.1 4.2 4.3 Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice" . Frontiers in Molecular Neuroscience . 10 : 351. doi :10.3389/fnmol.2017.00351 . PMC 5671512 PMID 29163028 . ↑ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis" . PLOS One . 11 (6): e0156912. doi :10.1371/journal.pone.0156912 . PMC 4896477 PMID 27272503 . ↑ Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction" . The Journal of Cell Biology . 117 (1): 143–55. doi :10.1083/jcb.117.1.143 . PMC 2289394 PMID 1313436 . ↑ de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience . 23 (27): 9133–45. PMID 14534247 .
Further reading
