BMP binding endothelial regulator is a protein that in humans is encoded by the BMPER gene .[1]
Transcription KLF15 is a strong and direct activator of BMPER expression which is inhibited by SP1 . BMPER is inhibited by endothelin-1 , which may be mediated by endothelin inhibition of KLF15.[2]
References External links Further reading
Nagase T, Kikuno R, Ohara O (Dec 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research . 8 (6): 319–27. doi :10.1093/dnares/8.6.319 . PMID 11853319 . Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C (Aug 2003). "BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation" . Molecular and Cellular Biology . 23 (16): 5664–79. doi :10.1128/MCB.23.16.5664-5679.2003 . PMC 166349 PMID 12897139 . Binnerts ME, Wen X, Canté-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F (Mar 2004). "Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins". Biochemical and Biophysical Research Communications . 315 (2): 272–80. doi :10.1016/j.bbrc.2004.01.048 . PMID 14766204 . Heinke J, Wehofsits L, Zhou Q, Zoeller C, Baar KM, Helbing T, Laib A, Augustin H, Bode C, Patterson C, Moser M (Oct 2008). "BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis". Circulation Research . 103 (8): 804–12. doi :10.1161/CIRCRESAHA.108.178434 . PMID 18787191 . Funari VA, Krakow D, Nevarez L, Chen Z, Funari TL, Vatanavicharn N, Wilcox WR, Rimoin DL, Nelson SF, Cohn DH (Oct 2010). "BMPER mutation in diaphanospondylodysostosis identified by ancestral autozygosity mapping and targeted high-throughput sequencing" . American Journal of Human Genetics . 87 (4): 532–7. doi :10.1016/j.ajhg.2010.08.015 . PMC 2948790 PMID 20869035 .
