V-set and immunoglobulin domain containing 1

V-set and immunoglobulin domain containing 1 is a protein that in humans is encoded by the VSIG1 gene. ^[1]

Function

This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in a normal stomach and testis, as well as in gastric, esophageal, and ovarian cancers. Alternatively spliced transcript variants, encoding different isoforms, have been found for this gene. [provided by RefSeq, Dec 2009].

Scanlan MJ, Ritter G, Yin BW, Williams C, Cohen LS, Coplan KA, Fortunato SR, Frosina D, Lee SY, Murray AE, Chua R, Filonenko VV, Sato E, Old LJ, Jungbluth AA (January 2006). "Glycoprotein A34, a novel target for antibody-based cancer immunotherapy". Cancer Immun. 6: 2. PMID 16405301.
Chen Y, Pan K, Li S, Xia J, Wang W, Chen J, Zhao J, Lü L, Wang D, Pan Q, Wang Q, Li Y, He J, Li Q (September 2012). "Decreased expression of V-set and immunoglobulin domain containing 1 (VSIG1) is associated with poor prognosis in primary gastric cancer". J Surg Oncol. 106 (3): 286–93. doi:10.1002/jso.22150. PMID 22095633.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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