Mucoepidermoid carcinoma natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: , Badria Munir M.B.B.S.[2] , Maria Fernanda Villarreal, M.D. [3]

Overview

If left untreated, patients with mucoepidermoid carcinoma may progress to develop sentinel metastasis to adjacent lymph nodes. Common complications of mucoepidermoid carcinoma include facial deformity, difficulty swallowing, and local lymph node metastasis. Prognosis will generally depend on the clinical stage, tumor size, and histological grade. The overall recurrence rate will depend on the stage. Low grade tumors have a 90-98% survival rate and a low rate of local recurrence.

Natural History

The majority of patients with mucoepidermoid carcinoma are initially asymptomatic.
Symptoms usually develop in the second or fifth decade of life, and initially patients complain of swallowing problems that are increased upon chewing activity.
If left untreated, patients with mucoepidermoid carcinoma may progress to develop sentinel lymph node metastasis.

Complications

Common complications of mucoepidermoid carcinoma include:^[1]

Prognosis

Prognosis will generally depend on the clinical stage, tumor size, and histological grade.^[1]
The overall recurrence rate depends on the stage of the tumor.^[1]^[2]

Low grade tumors have a 90-98% survival rate and a low rate of local recurrence.
High grade tumors have a 30-54% survival rate, and a high local recurrence rate.^[2]
The 5-year survival rate of patients with mucoepidermoid carcinoma is:^[3]

Stage I 75%
Stage II 59%
Stage III 57%
Stage IV 28%

References

↑ ^1.0 ^1.1 ^1.2 Plambeck K, Friedrich RE, Schmelzle R (1996). "Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients". J Craniomaxillofac Surg. 24 (3): 133–9. PMID 8842902.
↑ ^2.0 ^2.1 Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY (1990). "Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy". Arch. Otolaryngol. Head Neck Surg. 116 (3): 290–3. PMID 2306346.
↑ Wealey, W. V., Perzin, K. H. and Smith, L. (1970), Mucoepidermoid carcinoma of salivary gland origin. Classification, clinical-pathologic correlation, and results of treatment. Cancer, 26: 368–388. doi: 10.1002/1097-0142(197008)26:2<368::AID-CNCR2820260219>3.0.CO;2-K

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[pmid8842902-1] 1.0 ^1.1 ^1.2 Plambeck K, Friedrich RE, Schmelzle R (1996). "Mucoepidermoid carcinoma of salivary gland origin: classification, clinical-pathological correlation, treatment results and long-term follow-up in 55 patients". J Craniomaxillofac Surg. 24 (3): 133–9. PMID 8842902.

[pmid2306346-2] 2.0 ^2.1 Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY (1990). "Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy". Arch. Otolaryngol. Head Neck Surg. 116 (3): 290–3. PMID 2306346.

[tumor-3] Wealey, W. V., Perzin, K. H. and Smith, L. (1970), Mucoepidermoid carcinoma of salivary gland origin. Classification, clinical-pathologic correlation, and results of treatment. Cancer, 26: 368–388. doi: 10.1002/1097-0142(197008)26:2<368::AID-CNCR2820260219>3.0.CO;2-K

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