Non-Hodgkin lymphoma laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [3]

Overview

Laboratory tests for non-Hodgkin lymphoma include complete blood count (CBC), blood chemistry studies, HIV blood test, and hepatitis B blood test.

Laboratory Tests

Laboratory tests for non-Hodgkin lymphoma include the following:

Complete Blood Count

• In early stage of the disease the complete blood count (CBC) may be normal.
• Anemia may be seen secondary to involvement of bone marrow, autoimmune hemolysis and bleeding.
• Thrombocytopenia, leukopenia, or pancytopenia may be seen after bone marrow infiltration or autoimmune cytopenias.
• Lymphocytosis with circulating malignant cells seen in low grade lymphomas.
• Thrombocytosis may be seen as a paraneoplastic syndrome.

Blood Chemistry Studies

• Elevated lactate dehydrogenase (LDH)correlates with poor prognosis.
• Liver function test (LFT) results may be abnormal secondary to hepatic involvement.
• Hypercalcemia may be seen in patients with acute form of adult T-cell lymphoma-leukemia (ATLL).