Chronic neutrophilic leukemia historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Chronic neutrophilic leukemia(CNL) was first presented by Tuohy, in a case of splenomegaly and neutrophilic leukocytosis, in 1920. Although, It was named by Tanzer et al, in 1964. WHO introduced the criteria for the diagnosis of this disease as a myeloproliferative disorder in 2001. In 2013, CSF3R (colony stimulating factor 3 receptor) mutations was proposed that was found in the most CNL patients and made a huge change in diagnosis and treatment of this patient.
Historical Perspective
Discovery
- Chronic neutrophilic leukemia(CNL) was first presented by Tuohy, in a case of splenomegaly and neutrophilic leukocytosis, in 1920.Although, It was named by Tanzer et al, in 1964.
- In 2001, WHO introduced the criteria for diagnosis CNL as a myeloproliferative disorder that was revised in 2016.
- In 2013, CSF3R (colony stimulating factor 3 receptor) mutations was proposed that was found in the most CNL patients.