Merkel cell cancer laboratory tests
Merkel cell cancer Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Merkel cell cancer laboratory tests On the Web |
American Roentgen Ray Society Images of Merkel cell cancer laboratory tests |
Risk calculators and risk factors for Merkel cell cancer laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Laboratory findings consistent with the diagnosis of merkel cell cancer include immunohistochemistry, cytogenetic and molecular analysis, and [abnormal test 3]. .
Laboratory findings
Laboratory findings consistent with the diagnosis of merkel cell cancer include:
Immunohistochemistry
- Epithelial markers play an important role in the diagnosis of merkel cell cancer which include:[1]
- Cytokeratin AE1/AE3
- CAM 5.2
- Pan-cytokeratin
- Epithelial membrane antigen, and
- Ber-EP4
- Merkel cell carcinoma may also shows positive for neuroendocrine markers such as:[2]
- Chromogranin
- Synaptophysin
- Calcitonin and
- Vasoactive intestinal peptide
- Somatostatin receptors (SSTRs)
Cytogenetic and molecular analysis
- Many chromosomal abnormalities have been detected in merkel cell cancer but most commonly affected are:
References
- ↑ Weinbreck N, Marie B, Bressenot A, Montagne K, Joud A, Baumann C, Klein O, Vignaud JM (July 2008). "Immunohistochemical markers to distinguish between hemangioblastoma and metastatic clear-cell renal cell carcinoma in the brain: utility of aquaporin1 combined with cytokeratin AE1/AE3 immunostaining". Am. J. Surg. Pathol. 32 (7): 1051–9. doi:10.1097/PAS.0b013e3181609d7d. PMID 18496143.
- ↑ Gardair C, Samimi M, Touzé A, Coursaget P, Lorette G, Caille A, Wierzbicka E, Croué A, Avenel-Audran M, Aubin F, Kerdraon R, Estève E, Beneton N, Guyétant S (2015). "Somatostatin Receptors 2A and 5 Are Expressed in Merkel Cell Carcinoma with No Association with Disease Severity". Neuroendocrinology. 101 (3): 223–35. doi:10.1159/000381062. PMID 25765179.