Neuronal PAS domain protein 4

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Neuronal PAS domain protein 4 is a protein that in humans is encoded by the NPAS4 gene.

Function

NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008].

Further reading

• Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression". Mol. Cell. Biol. 24 (2): 608–16. PMC 343817. PMID 14701734.
• Bersten DC, Bruning JB, Peet DJ, Whitelaw ML (2014). "Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function". PLoS ONE. 9 (1): e85768. doi:10.1371/journal.pone.0085768. PMC 3894988. PMID 24465693.
• Klaric TS, Thomas PQ, Dottori M, Leong WK, Koblar SA, Lewis MD (2014). "A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells". Stem Cell Res Ther. 5 (3): 64. doi:10.1186/scrt453. PMC 4076635. PMID 24887558.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.