Fibroadenoma other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
The definitive diagnosis of fibroadenoma is confirmed by an ultrasound guided biopsy. Characteristic findings for fibroadenoma on microscopic histopathological analysis can be found here.[1]
Other Diagnostic Studies
Aspiration Cytology
- The definitive diagnosis of fibroadenoma is confirmed by an ultrasound guided biopsy. Characteristic findings for fibroadenoma on microscopic histopathological analysis can be found here.[1]
- In combination with clinical diagnosis of fibroadenoma, fine needle aspiration (FNA) can improve the sensitivity of the diagnosis to 86%, with a specificity of 76%.[2]
- Aspiration cytology may confuse fibroadenomas with other benign breast lesions, false diagnosis of a malignant process is uncommmon.[2]
- Indications for an ultrasound guided biopsy include:
- Rapidly enlarging mass
- Atypical findings on ultrasound such as non-circumscribed margins, complex solid and cystic components, posterior acoustic shadowing,
- A lesion greater than 3 cm in size, with no previous studies for comparison
- Patients preference
- The characteristic cytologic features of fibroadenomas include:[2]
- Clusters of spindle cells without inflammatory or fat cells. This is found in 96% of all fibroadenomas.
- Aggregates of cells with a papillary configuration resembling elk antler (antler horn clusters). Found in about 93%.
- Uniform cells with well-defined cytoplasm lying in rows and columns (honeycomb sheets). Found in about 95%