Acute lymphoblastic leukemia laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [4] Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [5] Carlos A Lopez, M.D. [6]
Ovierview
Laboratory findings consistent with the diagnosis of acute lymphoblastic leukemia include eosinophilia, lymphocytosis, red cell production reduced, thrombocytopenia. Chemistry panels with altered levels of uric acid, creatinine, blood urea nitrogen, potassium, phosphate, calcium, bilirubin, hepatic transaminases and ferritin.
Laboratory Findings
Laboratory findings consistent with the diagnosis of acute lymphoblastic leukemia include:[1]
- Anemia[2]
- Lymphocytosis
- Thrombocytopenia[3]
- Eosinophilia[4]
- A chemistry panel may also demonstrate altered concentrations of the following:[5]
- A spinal tap is often required to evaluate for central nervous system involvement.
![[1]](https://commons.wikimedia.org/wiki/Category:Acute_lymphoblastic_leukemia#/media/File:ALL-L1.jpg){kind=link}
![[2]](https://commons.wikimedia.org/wiki/File:ALL-KM-2.jpg){kind=link}
![[3]](https://commons.wikimedia.org/wiki/File:ALL-KM-3.jpg){kind=link}
References
- ↑ Chiaretti S, Zini G, Bassan R (2014). "Diagnosis and subclassification of acute lymphoblastic leukemia". Mediterr J Hematol Infect Dis. 6 (1): e2014073. doi:10.4084/MJHID.2014.073. PMC 4235437. PMID 25408859.
- ↑ Steele M, Narendran A (2012). "Mechanisms of defective erythropoiesis and anemia in pediatric acute lymphoblastic leukemia (ALL)". Ann Hematol. 91 (10): 1513–8. doi:10.1007/s00277-012-1475-5. PMID 22543829.
- ↑ Dubansky AS, Boyett JM, Falletta J, Mahoney DH, Land VJ, Pullen J; et al. (1989). "Isolated thrombocytopenia in children with acute lymphoblastic leukemia: a rare event in a Pediatric Oncology Group Study". Pediatrics. 84 (6): 1068–71. PMID 2587136.
- ↑ Rezamand A, Ghorashi Z, Ghorashi S, Nezami N (2013). "Eosinophilic presentation of acute lymphoblastic leukemia". Am J Case Rep. 14: 143–6. doi:10.12659/AJCR.883905. PMC 3715333. PMID 23869247.
- ↑ "National Cancer Institute".
- ↑ Ali A, Aziz SA, Khan A, Gelani S (2009). "Persistent hypokalemia in an acute lymphoblastic leukemia patient". Indian J Med Paediatr Oncol. 30 (3): 103–4. doi:10.4103/0971-5851.64255. PMC 2930287. PMID 20838546.