Fibroadenoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include juvenile fibroadenoma, complex fibroadenoma, myxoid fibroadenoma, and cellular fibroadenoma.

Classification

• Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include:

• Juvenile fibroadenoma
• Complex fibroadenoma
• Myxoid fibroadenoma
• Cellular fibroadenoma

• The table below differentiates between the four main subtypes of fibrodenoma according to microscopic histopathological analysis:

Fibroadenoma Subtype	Description
Juvenile fibroadenoma	Commonly found in ages 10 to 18 years. Stromal and epithelial hyperplasia Tapering, thin micropapillae (gynecomastoid hyperplasia) Mitoses is absent Occurs mostly in African Americans Rapid growth Associated with skin ulcerations and prominent veins
Complex fibroadenoma	Excessive proliferation of epithelial cells Apocrine metaplasia Cysts > 3 mm Calcification Sclerosing adenosis
Myxoid fibroadenoma	Myxoid stroma
Cellular fibroadenoma	Relatively high cellular component Increased mitotic rate Absence of calcification and sclerosing adenosis