Waldenström's macroglobulinemia physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Mirdula Sharma, MBBS [3]

Overview

Patients with Waldenström macroglobulinemia usually appear oriented to time, place, and person. Physical examination of patients with Waldenström's macroglobulinemia is usually remarkable for various findings depending on the degree of tissue infiltration by malignant tumor cells, hyperviscosity syndrome, and accumulation of paraprotein.

Physical Examination

General Appearance

Patients with Waldenström macroglobulinemia are generally well-appearing.^[1]

Skin

Purpura
Raynaud phenomenon
Petechiae - if platelet count is low

HEENT

Neck

Respiratory

Pleural effusion - in 3-5% of patients
Rales on auscultation

Cardiovascular system

Abdomen

Extremity

Raynaud phenomenon
Patients may have peripheral edema if disease is complicated by congestive heart failure.

Neuromuscular

Peripheral neuropathy - distal, symmetric, and sensorimotor^[2]

References

↑ Waldenström's macroglobulinemia. MedlinePlus (2015) https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 15th, 2015
↑ Coimbra J, Costa AP, Pita F, Rosado P, de Almeida LB (1995). "[Neuropathy in Waldenstrom's macroglobulinemia]". Acta Med Port (in Portuguese). 8 (4): 253–7. PMID 7625222.

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[aa-1] Waldenström's macroglobulinemia. MedlinePlus (2015) https://www.nlm.nih.gov/medlineplus/ency/article/000588.htm Accessed on November 15th, 2015

[cns-2] Coimbra J, Costa AP, Pita F, Rosado P, de Almeida LB (1995). "[Neuropathy in Waldenstrom's macroglobulinemia]". Acta Med Port (in Portuguese). 8 (4): 253–7. PMID 7625222.

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