Fibroadenoma historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Historical Perspective
- In 1994, Dupont et al addressed in their retrospective cohort study that fibroadenoma is associated with a long term risk of invasive breast cancer, with the risk further increased in women with complex fibroadenomas, a family history of breast cancer and those with proliferative disease. Later in a study with Carter, they found that the presence of atypic within a fibroadenoma cannot foretell the presence of one in the adjacent breast parenchyma. They also found that atypia within a fibroadenoma does not present a relevant risk of development of breast cancer greater than that of a fibroadenoma with no atypia within.[1][2]
- In 2008, Solar-Levy et al reported the presence of invasive lobular carcinoma in about 1.6% of patients with complex fibroadenomas and advised that any complex fibroadenoma with a high risk lesion on core biopsy should be excised.
References
- ↑ Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD, Rados MS; et al. (1994). "Long-term risk of breast cancer in women with fibroadenoma". N Engl J Med. 331 (1): 10–5. doi:10.1056/NEJM199407073310103. PMID 8202095.
- ↑ Carter BA, Page DL, Schuyler P, Parl FF, Simpson JF, Jensen RA; et al. (2001). "No elevation in long-term breast carcinoma risk for women with fibroadenomas that contain atypical hyperplasia". Cancer. 92 (1): 30–6. PMID 11443606.