Cancer of unknown primary origin medical therapy
Cancer of unknown primary origin Microchapters |
Differentiating Cancer of Unknown Primary Origin from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Roukoz A. Karam, M.D.[2]
Overview
There is no treatment for cancer of unknown primary origin; the mainstay of therapy is supportive care.
Medical Therapy
Medical Therapy
- There is no treatment for cancer of unknown primary origin; the mainstay of therapy is supportive care.[1]
- The treatment for cancer of unknown primary origin will depend on several factors, such as metastatic origin, biopsy findings, patients age, and performance status.
- Medical therapy for cancer of unknown primary origin should be adjusted on an individual basis and according to well-defined clinicopathologic subsets.[1]
- The table below summarizes different types of medical therapy strategies for cancer of unknown primary origin.
Treatment for cancer of unknown primary origin Adapted from the European Society of Medical Oncology[1] | |
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Sub-type | Proposed treatment |
Poorly differentiated carcinoma, predominately nodal disease |
Platinum based combination chemotherapy |
Peritoneal carcinomatosis in female |
Platinum based chemotherapy |
Isolated axillary nodal metastases in female |
Identical to breast cancer with similar nodal involvement |
Irradiation for N1-N2 disease. | |
Liver, bone, or multiple-site metastases of adenocarcinoma |
Low toxicity chemotherapy of palliative orientation or best supportive care are acceptable |