Epithelial ovarian cancer
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Hannan Javed, M.D.[2]
| Possible genetic alteration in epithelial ovarian cancers | ||
|---|---|---|
| Protein | Normal function | Result of mutation |
| Epidermal growth factor receptor (HER-1)[1][2] |
|
|
| Human Epidermal Growth Factor Receptor 2 (HER-2)[1][2] |
|
|
| Non-receptor tyrosine kinase Src[3][4] | Involved in regulation of
|
|
| CSF-1/fms[5][6][7] |
|
|
| ILGF/ILGFR | ||
| k-ras | ||
| b-raf | ||
| TGF-β | ||
| myc | ||
| Cyclin D/Cdk4/6 | ||
| Cyclin E/Cdk2 | ||
| Cyclin B/Cdk1 | ||
| p16 | ||
| p27 (kip-1) | ||
| p21 (WAF-1) | ||
| NFκB | ||
| NOEY(ARHI) | ||
| PIP3/Akt | ||
| PTEN | ||
| p53 | ||
| BRCA1 | ||
| BRCA2 | ||
| MLH1/MSH2 | ||
| Fas ligand | ||
| HLA-G | ||
| hTERT | ||
| VEGF/VEGFR | ||
| IL-8 | ||
| EphA2 | ||
| MMPs | ||
| αvβ3 | ||
| FAK | ||
| E-cadherin | ||
References
- ↑ 1.0 1.1 Wee P, Wang Z (May 2017). "Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways". Cancers (Basel). 9 (5). doi:10.3390/cancers9050052. PMC 5447962. PMID 28513565.
- ↑ 2.0 2.1 Iqbal N, Iqbal N (2014). "Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications". Mol Biol Int. 2014: 852748. doi:10.1155/2014/852748. PMC 4170925. PMID 25276427.
- ↑ Zan L, Wu H, Jiang J, Zhao S, Song Y, Teng G, Li H, Jia Y, Zhou M, Zhang X, Qi J, Wang J (July 2011). "Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema". Neurochem. Int. 58 (8): 872–9. doi:10.1016/j.neuint.2011.02.014. PMC 3100427. PMID 21334414.
- ↑ Reinecke JB, Katafiasz D, Naslavsky N, Caplan S (April 2014). "Regulation of Src trafficking and activation by the endocytic regulatory proteins MICAL-L1 and EHD1". J. Cell. Sci. 127 (Pt 8): 1684–98. doi:10.1242/jcs.133892. PMC 3986674. PMID 24481818.
- ↑ Saad AF, Hu W, Sood AK (December 2010). "Microenvironment and pathogenesis of epithelial ovarian cancer". Horm Cancer. 1 (6): 277–90. doi:10.1007/s12672-010-0054-2. PMC 3199131. PMID 21761359.
- ↑ Dwyer AR, Greenland EL, Pixley FJ (June 2017). "Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling". Cancers (Basel). 9 (6). doi:10.3390/cancers9060068. PMC 5483887. PMID 28629162.
- ↑ Abraham D, Zins K, Sioud M, Lucas T, Schäfer R, Stanley ER, Aharinejad S (March 2010). "Stromal cell-derived CSF-1 blockade prolongs xenograft survival of CSF-1-negative neuroblastoma". Int. J. Cancer. 126 (6): 1339–52. doi:10.1002/ijc.24859. PMC 3222589. PMID 19711348.