Desmoid tumor other diagnostic studies

	Desmoid tumor Microchapters
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Case #1

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

Antibodies including smooth muscle actin, desmin and KIT are often examined to aid in distinguishing desmoids from other tumors.

Characteristic features of desmoid tumors on immunohistochemistry and relevant antibodies
Other diagnostic tests	Associated characteristics features
Immunohistochemistry (aids histologic diagnosis)	Spindle cells on immunohistochemical stains show the following features: Positive for: vimentin and smooth muscle actin and nuclear beta-catenin but are generally negative for desmin, cytokeratins, and S-100 Regardless of the site, 90% of desmoids show nuclear reactivity (has relatively high specificity)
Antibodies	In order to distinguish desmoid tumors from other tumors, following antibodies are often examined: Smooth muscle actin Desmin KIT