Ovarian germ cell tumor medical therapy

Ovarian germ cell tumor Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Overview

The mainstay of therapy for ovarian germ cell tumor is chemotherapy.

Medical Therapy

• The mainstay of therapy for ovarian germ cell tumor is chemotherapy.
• There is no pharmacologic therapy for the mature teratoma.

Stage I ovarian germ cell tumors

• Dysgerminomas

• Unilateral salpingo-oophorectomy with adjuvant radiation therapy or chemotherapy

• Other germ cell tumors

• Unilateral salpingo-oophorectomy with adjuvant chemotherapy

Stage II ovarian germ cell tumors

• Dysgerminomas

• Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant radiation therapy or chemotherapy
• Unilateral salpingo-oophorectomy with adjuvant chemotherapy

• Other germ cell tumors

• Unilateral salpingo-oophorectomy with adjuvant chemotherapy

Stage III ovarian germ cell tumors

• Dysgerminomas

• Unilateral salpingo-oophorectomy with adjuvant chemotherapy

• Other germ cell tumors

• Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy, with or without neoadjuvant chemotherapy
• Unilateral salpingo-oophorectomy with adjuvant chemotherapy, with or without neoadjuvant chemotherapy

Stage IV ovarian germ cell tumors

• Dysgerminomas

• Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy
• Unilateral salpingo-oophorectomy with adjuvant chemotherapy

• Other germ cell tumors

• Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy with or without neoadjuvant chemotherapy
• Unilateral salpingo-oophorectomy with adjuvant chemotherapy with or without neoadjuvant chemotherapy