Gestational trophoblastic neoplasia history and symptoms

Gestational trophoblastic neoplasia Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Overview

Gestational trophoblastic neoplasia patients can present with history of previous pregnancies including hydatidiform mole (molar pregnancy) and miscarriage, history of previous gestational trophoblastic disease (GTD), and signs and symptoms that may suggest gestational trophoblastic disease (GTD). Symptoms of choriocarcinoma include vaginal bleeding, passing of tissue resembling a “bunch of grapes” from the vagina, and abdominal distension.

History

When obtaining history from a patient with suspected gestational trophoblastic neoplasia, specific areas of focus include:

• History of previous pregnancies, including hydatidiform mole (molar pregnancy) and miscarriage
• History of previous gestational trophoblastic disease (GTD)
• Reproductive factors that may increase the risk of gestational trophoblastic disease (GTD)
• A family history of gestational trophoblastic disease (GTD)
• Signs and symptoms that may suggest gestational trophoblastic disease (GTD)

Symptoms

Early Symptoms of Gestational Trophoblastic Neoplasia

• Vaginal bleeding
• Nausea and vomiting
• Passing of tissue resembling a “bunch of grapes” from the vagina
• Absent fetal movement during pregnancy
• Abdominal distension

Rare Symptoms of Gestational Trophoblastic Neoplasia

• Headache
• Edema of the hands and feet
• Abdominal or pelvic pain
• Vaginal discharge
• Overactive thyroid gland (hyperthyroidism) that causes:

• Tachycardia
• Sweating
• Shaking
• Heat intolerance
• Fever

Late Symptoms of Gestational Trophoblastic Neoplasia

• Hemoptysis
• Dry cough
• Chest pain
• Trouble breathing
• Headache
• Dizziness
• Jaundice
• Paralysis
• Seizure
• Dysarthria and dysphasia
• Vision problems
• Lump in the vagina